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REVIEW ARTICLE
Year : 2015  |  Volume : 1  |  Issue : 3  |  Page : 241-243

Human-induced pluripotent stem cells in modeling inherited cardiomyopathies


Department of Genomics and Molecular Medicine, Council of Scientific and Industrial Research, Institute of Genomics and Integrative Biology, New Delhi, India

Correspondence Address:
Shantanu Sengupta
Department of Genomics and Molecular Medicine, Council of Scientific and Industrial Research, Institute of Genomics and Integrative Biology, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2395-5414.177232

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Our current understanding of molecular mechanisms of cardiomyopathies has been elucidated from genetic animal models. Induced pluripotent stem cells (iPSCs) can provide a platform to improve our understanding of familial cardiomyopathies diseases. iPSCs are a type of pluripotent stem cell that can be generated directly from adult cells. Identification of mutations in patients with inherited cardiomyopathies has revealed substantial molecular complexity. In spite of the complexity, the advances of iPSC-based technology may improve our understanding of familial cardiomyopathies.


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