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| BRIEF COMMUNICATION |
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| Year : 2023 | Volume
: 9
| Issue : 1 | Page : 37-40 |
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Annual Report of the Heart and Lung Transplant Registry (INTRAN) of the indian society for heart and lung transplantation 2023
| Date of Submission | 02-Apr-2023 |
| Date of Acceptance | 02-Apr-2023 |
| Date of Web Publication | 04-May-2023 |
Correspondence Address:
Indian Society for Heart and Lung Transplantation
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jpcs.jpcs_30_23
This is a registry report of the Indian Society for Heart and Lung Transplantation. The data reflects thoracic transplants done in India since 1994. It is a voluntary cloud-based registry. This is the data on total number of heart and lung transplant and left ventricular assist device (LVAD) implants done till March 2023. Till date, India has done 1328 heart transplants, 475 lung transplants, 128 LVAD implants, and 61 lung transplants for COVID lung disease.
Keywords: Data, heart, India, Indian Society for Heart and Lung Transplantation, lung, registry, transplant
How to cite this article:
. Annual Report of the Heart and Lung Transplant Registry (INTRAN) of the indian society for heart and lung transplantation 2023. J Pract Cardiovasc Sci 2023;9:37-40 |
How to cite this URL:
. Annual Report of the Heart and Lung Transplant Registry (INTRAN) of the indian society for heart and lung transplantation 2023. J Pract Cardiovasc Sci [serial online] 2023 [cited 2023 Jun 10];9:37-40. Available from: https://www.j-pcs.org/text.asp?2023/9/1/37/375807 |
Indian Society for Heart and Lung Transplantation
| Introduction | |  |
Heart transplant was first done on the night of December 2, 1967 by Christiaan Barnard. He went on to do 53 transplants. Soon after in 1968, PK Sen did the first heart transplant in India and the 6th in the world. The patient died and the heart transplant program in India never took off. He was the fourth surgeon in the world to do a heart transplant. In 1994, the Organ Transplant Bill was passed and the team lead by Venugopal at AIIMS did the first successful Heart Transplant in India, where the heart was harvested after declaration of Brain Death. The patient lived on for more than a decade and the heart transplant program in India had taken off. Left ventricular (LV) assist device implantation also started in India at AIIMS by 1994–1995. In 1999, KM Cherian did the first double lung transplant and also the first heart lung transplant and started the lung transplant program in India.[1],[2],[3],[4],[5]
Since then, India is one of the few countries in Asia with a very active heart and lung transplant program with more than 70 approved transplant centers. This article is a report of the Indian Heart and Lung Transplant Registry (INTRAN) of the Indian Society for Heart and Lung Transplantation.
| Methods | | |
The Indian Heart and Lung transplant Registry (INTRAN) is a cloud-based registry, where each transplant center fills the data on their heart and lung transplant numbers on a Google sheet. The data cover the total number of transplants done at each center. This is a voluntary registry and the data as reflected in the registry are published at regular intervals. The first report was published in 2021 and this is the second report.
| Results | | |
This is the data on total number of heart and lung transplant and LV assist device implants (LVAD) done till March 2023. There are more than 70 centers in India approved for thoracic transplants [Table 1] and [Figure 1]. Till date, India has done 1328 heart transplants, 475 lung transplants, 128 LVAD implants, and 61 lung transplants for COVID lung disease. [Table 2] reflects the data published in 2021, the current data in 2023, and also the data from years 2021 to 2022 separately.
| Discussion | | |
India has done 1328 heart transplants, 475 lung transplants, 128 LVAD implants, and 61 lung transplants for COVID lung disease. There was a dip in organ transplantation during the COVID epidemic, but the numbers have picked up again.
While the current registry does not contain any additional data, individual hospitals have published data on survival and complications.[6],[7],[8],[9],[10],[11],[12] The cost of a heart transplant is about 15 lakhs with certain variations at different centers.[7],[12] Monthly costs initially are about 30,000 INR, and later reduce to about 15,000 INR.[7] Most centers follow a regime of tacrolimus, mycophenolate mofetil, and steroids along with 3 − 6 months of valganciclovir, voriconazole, and co-trimoxazole. Some centers use acyclovir and fluconazole. Steroids were tapered by 1–6 months to 0.1 mg/kg/day in all patients. Many centers stop steroids at 1 year. Survival at 1 year is about 81%–90% at many centers.[6],[7],[8],[9] For lung transplant, one of the published series showed a 3 year survival of 76.2%.[13] LVADs are also being implanted in all parts of India, although numbers are lower due to the cost.[14]
| Conclusions | | |
India is doing about 90–100 heart transplants every year. There are more than 70 centers doing transplants. About 26 centers have done more than 10 heart transplants each. India does more than 60–80 lung transplants and about 100 heart transplants every year. Survival at 1 year for heart transplant is about 80%–90%, and for lung transplant, it is about 76% at 3 years.
Ethics clearance
Nil.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
| References | | |
| 1. | Annual report of the Indian heart and lung transplant registry. J Pract Cardiovasc Sci 2021;7:175-7.  |
| 2. | Jones DS, Sivaramakrishnan K. Transplant buccaneers: P.K. Sen and India's first heart transplant, February 1968. J Hist Med Allied Sci 2018;73:303-32. |
| 3. | Kalra A, Seth S, Hote MP, Airan B. The story of heart transplantation: From Cape Town to Cape Comorin. J Prac Cardiovasc Sci 2016;2:120. |
| 4. | Venugopal P. The first successful heart transplant in India. Natl Med J India 1994;7:213-5. |
| 5. | Nagamalesh UM. 25-year history of heart transplant in India: Lessons learned. J Prac Cardiovasc Sci 2021;7:1. |
| 6. | Ratnagiri RK, Dutta P, Attawar S. Heart transplant in India: Gleneagles global experience. J Prac Cardiovasc Sci 2019;5:91. |
| 7. | Rabbani SS, Singh SP, Seth S, Goyal A, Sahu MK, Hote MP. One year outcomes following orthotopic heart transplantation at a tertiary care Center in India. J Pract Cardiovasc Sci 2021;7:47. [Full text] |
| 8. | Airan B, Singh SP, Seth S, Hote MP, Sahu MK, Rajashekar P, et al. Heart transplant in India: Lessons learned. J Pract Cardiovasc Sci 2017;3:94-9. [Full text] |
| 9. | Balakrishnan K. Heart transplantation in India-are we there yet? Indian J Thorac Cardiovasc Surg 2020;36:159-65. |
| 10. | Balakrishnan KR, Rao KS, Kumar RR. Heart transplantation: Current status in India. Indian J Surg 2023;5:1-4. |
| 11. | Balakrishnan KR, Sureshrao KG, Ravikumar R, Muralikrishna T, Ganapathy Subramaniam K, Mohan R, et al. Medium term results following heart transplantation for end stage heart failure: A single Center experience of 257 patients. Indian Heart J 2020;72:524-34. |
| 12. | Balakrishnan K, Nageswaran C. Cost analysis of 163 consecutive heart transplant operationsin an Indian setting. Indian J Thorac Cardiovasc Surg 2020;36:200-9. |
| 13. | Sunder T, Ramesh PT, Kuppuswamy MK, Choudhary SK, Hote MP, Devagourou V, et al. Lung transplantation: The Indian experience and suggested guidelines Part II A: The technique of lung transplantation. J Pract Cardiovasc Sci 2020;6:278. |
| 14. | Jose J, Magoon R, Kohli JK, Kashav R. The tale of Kantrowitz brothers: A dream to support the failing heart! J Pract Cardiovasc Sci 2020;6:299. |
[Figure 1]
[Table 1], [Table 2]
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